Orlistat (Xenical) received an FDA panel's recommendation for approval in May. The FDA estimates that 6.6 million prescriptions for fen/phen were filled in 1996. It is this combination that was identified as a possible cause of serious heart valve problems by doctors last week. The rationale for using the two drugs was that they might work more effectively together with fewer side effects. The two drugs are not sold in one pill a prescription for each is needed. Fen/phen is an informal name for a combination of low doses of phentermine and fenfluramine. In 1996, 2.4 million prescriptions were filled at a cost of $134 million. The manufacturer recommended it for people with a body mass index of 30 or higher, and for people with a BMI of 27 to 29 with such problems as hypertension and diabetes. A close chemical relative of fenfluramine, it was approved in April 1996 for use in losing weight along with a reduced-calorie diet for as long as one year. Dexfenfluramine (brand name Redux) is a serotonin-reuptake inhibitor like the popular antidepressant Prozac it increases the amount of serotonin in the brain. In 1996, 7 million prescriptions were filled for fenfluramine at a total cost of $188 million. Fenfluramine, sold under the brand name Pondimin, was approved by the FDA in 1973 for short-term use in dieting. Instead they affect a neurotransmitter chemical in the body called serotonin, which is believed to influence how satisfied people feel after eating. Serotonin drugs (such as fenfluramine and dexfenfluramine) are not stimulants. In 1996, 11 million prescriptions for phentermine were filled in the United States at a total retail cost of $124 million. Among other drugs of this type are phendimetrazine, mazindol and the over-the-counter diet aid phenylpropanolamine (Acutrim, Dexatrim). Amphetamine-like drugs: Phentermine was first approved by the Food and Drug Administration in 1959 as "a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction." It is sold under the brand names Ionamin, Adipex, Fastin, Banobese, Obenix and Zantryl. Two million prescriptions were filled in 1996 at a total retail cost of $59 million. Amphetamines are prescribed for other problems than obesity, such as attention deficit disorder and narcolepsy. Potential side effects include heart palpitations, elevation of blood pressure, gastrointestinal disturbances and insomnia.
Among the best known: Amphetamines (amphetamine, dextroamphetamine, methamphetamine) are strong stimulants that are no longer recommended by most authorities for weight control because they are highly addictive. While they generally suppress appetite, some may also alter the way the body burns calories. Most of these drugs affect the body's nervous system.
Using both together can significantly increase the risk of increased heart rate and blood pressure.Americans spent at least $467 million on prescription obesity drugs in 1996 and another $32 million on over-the-counter diet aids.
Taking Phentermine With AdderallĪs discussed above, phentermine should not be used with Adderall due to the potential of additive side effects. Phentermine is relatively long-lasting and should be dosed in the morning to prevent sleeping problems at bedtime. It is commonly used for weight loss, in conjunction with diet and exercise. In fact, it is commonly described as having "amphetamine-like" effects on mood. Phentermine is chemically similar to amphetamine and also has a similar mechanism of action. It is available as both an immediate-release tablet and as extended-release capsules (Adderall XR). AdderallĪdderall is a mixture of both amphetamine and dextroamphetamine salts and is used mainly to treat attention-deficit hyperactivity disorder (ADHD).Īdderall works by stimulating the release of neurotransmitters such as dopamine, norepinephrine and serotonin. Taking more than one sympathomimetic drug, such as phentermine with Adderall can greatly increase the risk of serious cardiovascular and central nervous system side effects such as high blood pressure, increased heart rate, and irritability.īelow, we discuss additional information about both drugs. They have very similar effects on the body, such as increasing the amount of various neurotransmitters in the brain, such as dopamine and norepinephrine. In the vast majority of cases, they should not be taken together.īoth phentermine and Adderall are stimulant medications, classified as sympathomimetics. There is a significant interaction between phentermine and Adderall (amphetamine salts).
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